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Research Associate II - Hematopoiesis - Merchant Lab

Cedars-Sinai


Location:
Los Angeles, CA 90006
Date:
05/03/2019
2019-05-032020-07-15
Categories:
  • Biotechnology / Science
  • Administrative / Clerical
Cedars-Sinai
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Job Details

The Merchant lab seeks a Research Associate with and interest in hematopoiesis, stem cell biology, and/or myeloproliferative diseases to join an NIH funded project examining the role of Hedgehog signaling in the bone marrow microenvironment. Studies in the lab make use of transgenic mouse models and primary patients samples. There will be additional opportunities to study patient samples from patients treated with hedgehog inhibitors. Studies of the bone marrow microenvironment will be enabled but the use of imaging mass cytometry/CyTOF. Imaging mass cytometry allows for highly multiplexed (35+ markers) imaging of immune and tumor cells, with spatial information and subcellular resolution making it the ideal technology for studying stem cells and immune cells in their cellular niches within the bone marrow. Imaging mass cytometry can be applied to all tissue types including cell lines, organoids, frozen section and FFPE fixed archival tissue. Primary Duties and Responsibilities: Breeding, genotyping, blood sampling and bone marrow harvesting from transgenic mice. Apply standard molecular and cellular biology methods (RT-PCR, Western bloting, cell culture and transduction, expression profiling) to profile the hedgehog signaling pathway. Performs conjugations and validation of antibodies and other reagents used for mass cytometry work. Keeps accurate and detailed records of experiments and results, and assist in identifying and troubleshooting of unexpected results. Orders laboratory supplies and supports laboratory operations. Maintains lab equipment and related records and may coordinate use of lab equipment. Assists in the operation of specialized equipment and machinery including mass cytometry system. Assists in preparation of data for publication and/or presentation at scholarly meetings. Observes and complies with safety standards and procedures. Orients research laboratory assistants or lower level research associates and undergraduate student researchers on day-to-day lab operations and routine procedures. **Job Qualifications:** Minimum Bachelor of Science Degree **Work Experience:** Minimum of 2 years Laboratory or related research experience **Skills, Knowledge and Abilities:** Familiar with routine laboratory procedures, experimental protocols, and overall lab organization. Applicant must be highly motivated and able to work independently. Must have superior interpersonal, communication and organization skills and the ability to work across company disciplines and functional units, and computer application experience. Must possess computer skills to include, but not limited to, Excel and Word. Ability to simultaneously manage multiple clerical trials, and attention to details. Cedars-Sinai is an EEO employer. Cedars-Sinai does not unlawfully discriminate on the basis of the race, religion, color, national origin, citizenship, ancestry, physical or mental disability, legally protected medical condition (cancer-related or genetic characteristics or any genetic information), marital status, sex, gender, sexual orientation, gender identity, gender expression, pregnancy, age (40 or older), military and/or veteran status or any other basis protected by federal or state law.
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